Metal-free oxidative synthesis of quinazolinones via dual ..

medium for the synthesis of quinazolinones
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Copper-Catalyzed Domino Synthesis of Quinazolinones …

AB - 4-Quinazolinones modified with 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole or 2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine rings and their N-oxyl derivatives were synthesized and some of them evaluated for protecting activity against H2O2 induced cell death on WRL-68 human liver cell line. Compounds 15a, 15c and 15d exhibited remarkably inhibitory effects on PARP enzyme in vitro.

Synthesis and study of new 4-quinazolinone inhibitors of the DNA repairenzyme poly(ADP-ribose) ..
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Synthesis of quinazolines - Organic Chemistry Portal

According to 1HNMR data, aromatic hydrogens at positions 9 and 13 of the phenyl ring (ring A) are seen as two separate doublets in 1 HNMR spectra due to the neighboring effects of this chiral center (Fig. , ). This neighboring effect is also observed for two hydrogens of the benzylic CH2 next to the ring B and the aliphatic CH2 at position 15 of the propyl side chain (Fig. , ).

21/12/2017 · 2004 Fused pyrimidine derivatives Fused pyrimidine derivatives R 0515 A Novel Method for the Synthesis of 4(3H)-Quinazolinones
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4-Quinazolinones modified with 2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole or 2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine rings and their N-oxyl derivatives were synthesized and some of them evaluated for protecting activity against H2O2 induced cell death on WRL-68 human liver cell line. Compounds 15a, 15c and 15d exhibited remarkably inhibitory effects on PARP enzyme in vitro.

The present invention provides intermediates, synthetic methods and novel quinazolinone compositions of matter.
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Aerobic Copper-Catalyzed Organic Reactions - …

Marisa Kozlowski received an A.B. in Chemistry from Cornell University in 1989 and a Ph.D. under the direction of Paul Bartlett from the University of California at Berkeley in 1994. After a NSF postdoctoral fellowship with David A. Evans at Harvard University, she joined the faculty at the University of Pennsylvania in 1997 and is currently Professor of Chemistry. The Kozlowski group research focuses on the design of new catalysts and transformations. She has also coauthored “Fundamentals of Asymmetric Catalysis” with Patrick Walsh.

Synthesis of some new 2,3-disubstituted …

In the third step 1,3 benzoxazine-4(one) 3 was refluxed with two different amines to give the corresponding quinazolinone 4a and 4b as a result of a nucleophilic substitution and subsequently dehydration of compound.

Synthesis of some new 2,3-disubstituted-4 ..

Ryan R. Walvoord was born in 1986 in the small town of Williamson, NY. He received a B.S. in Chemistry from the Rochester Institute of Technology in 2007, where he performed undergraduate research in the laboratories of Professor Christina G. Collison. In the same year, he began his graduate studies at the University of Pennsylvania under the guidance of Professor Marisa C. Kozlowski. His research in the Kozlowski group has focused on the synthesis and chemistry of arylnitromethanes, as well as the spectroscopic investigation of hydrogen bonding using colorimetric sensors.

Quinazolines are frequently used in medicine ..

Several synthetic methods have been reported for preparing these pharmacologically active substances(). The synthesis of quinazolinones may be performed by cyclization of benzene or pyrimidine substrates containing appropriate substituents, by using benzoxazin-4(one) (benzoxazinone) or by modification of appropriate derivatives of other heterocyclic systems(). Among various methods for quinazolinone synthesis, application of benzoxazinone has been repeatedly reported.