Toluenesulphonylmethyl isocyanide (TOSMIC) and the …

Toluenesulphonylmethyl isocyanide (TOSMIC) and the van Leusen MCR The Chemistry of TOSMIC

The first total synthesis of racemic perophoramidine is described

Ryan R. Walvoord was born in 1986 in the small town of Williamson, NY. He received a B.S. in Chemistry from the Rochester Institute of Technology in 2007, where he performed undergraduate research in the laboratories of Professor Christina G. Collison. In the same year, he began his graduate studies at the University of Pennsylvania under the guidance of Professor Marisa C. Kozlowski. His research in the Kozlowski group has focused on the synthesis and chemistry of arylnitromethanes, as well as the spectroscopic investigation of hydrogen bonding using colorimetric sensors.

Benzyl synthesis essay isocyanide. Good question, courtesy of a 7th grader's compare/contrast essay: How come nobody builds snowcastles or sandmen?

Aerobic Copper-Catalyzed Organic Reactions - …

AB - Multicomponent reactions (MCRs) are extremely popular owing to their facile execution, high atom-efficiency and the high diversity of products. MCRs can be used to access various heterocycles and highly functionalized scaffolds, and thus have been invaluable tools in total synthesis, drug discovery and bioconjugation. Traditional isocyanide-based MCRs utilize an external nucleophile attacking the reactive nitrilium ion, the key intermediate formed in the reaction of the imine and the isocyanide. However, when reactants with multiple nucleophilic groups (bisfunctional reactants) are used in the MCR, the nitrilium intermediate can be trapped by an intramolecular nucleophilic attack to form various heterocycles. The implications of nitrilium trapping along with widely applied conventional isocyanide-based MCRs in drug design are discussed in this review.

N2 - Multicomponent reactions (MCRs) are extremely popular owing to their facile execution, high atom-efficiency and the high diversity of products. MCRs can be used to access various heterocycles and highly functionalized scaffolds, and thus have been invaluable tools in total synthesis, drug discovery and bioconjugation. Traditional isocyanide-based MCRs utilize an external nucleophile attacking the reactive nitrilium ion, the key intermediate formed in the reaction of the imine and the isocyanide. However, when reactants with multiple nucleophilic groups (bisfunctional reactants) are used in the MCR, the nitrilium intermediate can be trapped by an intramolecular nucleophilic attack to form various heterocycles. The implications of nitrilium trapping along with widely applied conventional isocyanide-based MCRs in drug design are discussed in this review.