EP300 Gene - GeneCards | EP300 Protein | EP300 Antibody

Curcumin, the yellow color pigment of turmeric, is produced industrially from turmeric oleoresin

dextro,laevo-alpha-tocopherol 10191-41-0

The chemistry of garcinol and its synthetic chalcone analogs has been detailed in an earlier review []. In brief, as compared to the native chalcones fluorinated 2 hydroxychalcones have been reported to display increased antioxidative potential and bioavailability, which was exhibited effectively in pancreatic (BXPC 3) and breast cancer (BT-20) cell lines [].

Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives.

Food Additive: Functional use(s) - nutrient supplements, antioxidants

Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, diabetes, AIDS, and cardiac hypertrophy. We describe the synthesis and characterization of a set of p300-HAT-specific small-molecule inhibitors from a natural nonspecific HAT inhibitor, garcinol, which is highly toxic to cells. We show that the specific inhibitor selectively represses the p300-mediated acetylation of p53 in vivo. Furthermore, inhibition of p300-HAT down regulates several genes but significantly a few important genes are also upregulated. Remarkably, these inhibitors were found to be nontoxic to T cells, inhibit histone acetylation of HIV infected cells, and consequently inhibit the multiplication of HIV.

N2 - Reversible acetylation of histone and nonhistone proteins plays pivotal role in cellular homeostasis. Dysfunction of histone acetyltransferases (HATs) leads to several diseases including cancer, neurodegenaration, asthma, diabetes, AIDS, and cardiac hypertrophy. We describe the synthesis and characterization of a set of p300-HAT-specific small-molecule inhibitors from a natural nonspecific HAT inhibitor, garcinol, which is highly toxic to cells. We show that the specific inhibitor selectively represses the p300-mediated acetylation of p53 in vivo. Furthermore, inhibition of p300-HAT down regulates several genes but significantly a few important genes are also upregulated. Remarkably, these inhibitors were found to be nontoxic to T cells, inhibit histone acetylation of HIV infected cells, and consequently inhibit the multiplication of HIV.