25/04/2014 · Synthesis of acetylsalicylic acid ..
Further Analysis THE END Presented by MY LIFE: YOU LIGHT IT UP Conclusion The overall objectives of this experiment were to synthesize aspirin, to perform a crude purity test on said aspirin, to standardize and prepare solutions of both NaOH and HCL, and to qualitatively determine the purity of the aspirin by finding the percentage of acetylsalicylic acid in the aspirin.
A Greener Synthesis of Acetylsalicylic Acid | Ward's …
They may then use a quick confirmatory test to examine for the presence of salicylic acid, which can be used to synthesize acetylsalicylic acid.
An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. It is the two-step synthesis of aspirin starting from oil of wintergreen. The mechanism for this synthesis provides examples of three major classes of chemical reactions: hydrolysis, condensation, and proton transfer. To understand the chemistry, the student must be able to recognize the common molecular framework shared by oil of wintergreen, salicylic acid, and aspirin and to identify the -OH and -CO2 sites where chemical changes occur. The experiment differs in three ways from traditional aspirin synthesis experiments for general chemistry. It is designed to be performed early rather than late; it starts from a naturally occurring material and requires two steps rather than one; and it utilizes FTIR spectroscopy to distinguish among oil of wintergreen starting material, salicylic acid intermediate, and aspirin product. The use of FTIR spectroscopy introduces students to a modern analytical technique that is currently used in research involving aspirin.