Quinoline synthesis - Organic chemistry
The synthesis of (I) has been described by Usachev & Sosnovskikh (2004); alsosee Sosnovskikh et al. (2005). In the present study, (I) was obtainedas a side-product when the thione was recrystallized from THF in the presenceof copper(II) chloride.
hydrocarbons: alkanes, alkenes, carotenoids - Lipid
Proteus mirabilis: Overall, the majority of P. mirabilis isolates from the past two decade have been susceptible to commonly used antibiotics (). SENTRY data from the US and EU of isolates collected in 2009-2011 reported ), and a study of P. mirabilis catheter-associated UTI isolates from Poland similarly reported only 14% of isolates being resistant to amikacin. However, vancomycin, teicoplanin, linezolid, quinupristin/ dalfopristin, daptomycin, clindamycin, metronidazole, macrolides and ketolides do not have clinically useful activity against >P. mirabilis, and a high level of resistance (>60% of isolates) has been observed for cefuroxime, tetracycline, polymyxin B, colistin sulfate, and nitrofurantoin (). The new glycylcycline, , also has surprisingly poor in vitro activity, compared to its activity against other Gram negative bacilli (). High levels of ciprofloxacin resistance have been reported in Poland (), though norfloxacin remained effective against these isolates (), and qnr quinolone resistance genes have been identified in P. mirabilis isolates (, ).A compendium of antibiotic resistance of P. mirabilis is given in .
A series of new1-methyl-2-alkenyl-4(1H)-quinolones lacking carboxyl,fluorine and piperazinyl at position-3, -6 and -7, respectively, have beensynthesized and tested in vitro against fast growing species ofmycobacteria.