Physical and chemical data on 2-propanol are given in Table 1.

2-Propanol has been identified as a metabolic product of a variety of microorganisms.

Data on the behaviour of 2-propanol in soil are scarce.

Simultaneous exposure of rats to ethanol in the drinking-water (5%) and atmospheric 2-propanol at 738 mg/m3 (300 ppm) for 5 - 21 weeks significantly increased the rates of elimination of 2-propanol and acetone [224].

4.3.2 Bioaccumulation 2-Propanol is completely miscible with water.

In rats, the half-life of 2-propanol was 1.5 h at an intraperitoneal dose of 500 mg/kg body weight and increased to 2.5 h at a dose of 1500 mg/kg body weight.

When 4 volunteers ingested an artificial liquor containing 40% 2-propanol, acetone was detectable in exhaled air from 15 min after exposure and in the urine from 1 h after exposure [132].

No analysis for 2-propanol was reported for this open system [141].

Adsorption of 2-propanol on soil particles is poor but it should be mobile in soil and it has been shown to increase the permeability of soil to some aromatic hydrocarbons.

This may be due to the membrane effects of 2-propanol.

On the basis of these data, it can be concluded that, except in cases of accident and inappropriate disposal, 2-propanol does not present a risk to naturally occurring organisms at concentrations that usually occur in the environment.

2-Propanol depresses the central nervous system.

Hydrolysis and photolysis are not important in the removal of 2-propanol from water and soil but removal occurs quite rapidly by aerobic and anaerobic biodegradation, especially after adaptation of initially seeded microorganisms (section 4.3.1).

Patch tests were positive for 2-propanol.

By reacting with hydroxyl radicals and through rain-out, 2-propanol will disappear rapidly from the atmosphere, with a residence time of less than 2.5 days (section 4.2).

(1982) Isopropanol and isopropanol deaths: ten years' experience.

The Task Group considers it unlikely that 2-propanol will pose a serious health risk to the general population under exposure conditions likely to be encountered.

(1987) Chemical market profile: isopropanol.

There are adequate data to indicate that the strong acid process for the production of 2-propanol is causally associated with the induction of paranasal sinus cancer in human beings, probably due to exposure to the intermediate, di-2-propyl sulfate, an alkylating agent and not to 2-propanol itself (section 9.2.1).

(1966) Aerated stabilization of synthetic organic chemical wastes.

DGEP (1987) Review of literature data on 2-propanol, Leidschendam, Netherlands, Directorate-General of Environmental Protection, Ministry of Housing, Physical Planning and Environment.