Arachidonic Acid and Protein Synthesis
Thus, a nomenclature system was proposed to differentiate all the possible structures (). As increased levels of isofurans were detected in brain tissue of patients affected by several neural diseases, the determination of these molecules may be of value in appreciating oxidative damages to brain tissue ().
The biosynthesis, the nomenclature, the chemical synthesis of furanoids from -linolenic acid (C18:3 n-3), arachidonic acid (C20:4 n-6), adrenic acid (22:4 n-6) and docosahexaenoic acid (22:6 n-3) as well as their identification and implication in biological systems are highlighted in a review (., Biochimie 2016, 130, 49).
Arachidonic acid: contents in brief - Tuscany Diet
Thus,red blood cells were proposed to be a reservoir for epoxides which mayparticipate to vasoregulation.
Besides arachidonic acid, epoxide derivatives have been synthesized from EPA(20:5n-3) () and DHA (22:6n-3) ().
4-HNE was discovered in 1982 in autoxidized linseed oil (Nakamura T et al., Bull JapSoc Sci Fish 1982, 48, 1357) and, later, was reported to be formed from linoleic andarachidonic acids (Esterbauer H et al., Biochim Biophys Acta 1986, 876, 154).
At very low concentrations (below 0.1 mM), 4-HNE was shownto have various effects, such as chemotaxis and stimulation of guanylate cyclase andphospholipase C.