Synthesis of some disubstituted 3,4,5,6 ..

B., Direct Synthesis of 1,5-Disubstituted-4-magnesio-1,2,3-triazoles, Revisited.
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Synthesis of 1,3-oxazoles - Organic Chemistry Portal

New Syntheses of Alkylaryl and Diaryl Disubstituted Phenols and Ethyl Salicylates The sodium acetate- or triethylamine-catalyzed reaction of the chalcones and chalcone analogues 1a-n with 1-(2-oxopropyl)pyridinium chloride (2) or 1-(3-ethoxycarbonyl-2-oxopropyl)pyridinium bromide (3) gives the 3,5-disubstituted phenols (6a-g) or the 4,6-disubstituted ethyl 2-hydroxybenzoates (7a-1) in yields from 25 to 83α. Both reactions fail for chalcones with one o-substituted aryl substituent or for p,p′-dinitro-substituted diarylchalcones.

RESEARCH ORIGINAL RESEARCH Synthesis of 3,5-disubstituted isoxazolines as ..
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Synthesis of Benzofurans - Organic Chemistry Portal

A novel series of 5-(5-substituted-1,3,4-oxadiazol-2-yl)benzene-1,2,3-triols (3n-z) was designed, synthesized, and evaluated for its potential antioxidant activities. Structural modifications at position 5 of the 1,3,4-oxadiazole scaffold (linked to a fixed antioxidant 3,4,5-trihydroxyphenyl moiety at position 2 of the ring) was expected to give new 1,3,4-oxadiazole derivatives with a wide spectrum of biological antioxidant activities. Undoubted elucidation and full confirmation of the chemical structures of all the newly synthesized compounds were accomplished using the spectroscopical and elemental analyses. The pharmacological screening for evaluation of the antioxidant activity of these new thirteen target 5-substituted-2-(3,4,5-trihydroxyphenyl)-1,3,4-oxadiazoles (3n-z) was done by using two of the most common antioxidant assays. The results of both assays showed that compounds 3w,s,u (the fumaric, malonic, and citric acids-derived 1,3,4-oxadiazoles, respectively) surprisingly exhibited very high and significant antioxidant activities, and they could be very promising lead and parent compounds for the design and synthesis of new antioxidant agents by further biological evaluations, structural modifications, and computational studies.

11/12/2017 · Synthesis of 2,4-disubstituted thiophenols and solid state ..
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A Convenient Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles via 1,3-Dipolar Cycloaddition/Coupling of Alkynes, Phenylboronic Acids, and Sodium Azide Catalyzed by Cu(I)/Cu(II).

Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted ..
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