The rate-limiting step in serotonin synthesis involves the enzyme ..
There are probably also costs & benefits involved in synthesizing, transporting and recycling various neurotranmitters in the differing chemical mileus of the brain.
the rate-limiting enzyme in serotonin synthesis ..
The current state of knowledge about serotonin syndrome is mostly limited to case reports. Full understanding of its molecular biologic mechanisms is probably a number of years away. It is currently surmised that serotonin syndrome occurs when brain synapses are flooded by high levels of the endogenous neurotransmitter serotonin. This only occurs through the action of serotonergic drugs.
Serotonin concentration in the brain is far moresensitive to the effects of diet than any other monoamine neurotransmitter —and can be increased up to 10-fold by dietary supplementation in laboratoryanimals.
Serotonin: Facts, What Does Serotonin Do? - Medical …
Serotonin synthesis is a 2-step process, the first step of whichrequires the enzyme tryptophan hydroxylase with oxygen, iron and THBas co-factors.
1.1 Benzodiazepines, Flumazenil – L’Eggo my Benzo
Melatonin is synthesized from serotonin in a 2-step process that takes an acetyl group from acetyl-CoA and a methyl group from by (S−Adenosyl Methionine).
Glossary | Linus Pauling Institute | Oregon State University
The effectiveness of these neurotransmitters against depression seems to be due to both decreased functional activity of beta-postsynaptic norepinephrine receptors and increased activity of type−2 serotonin receptors in the limbic regions of the brain.