Acute acetylsalicylic acid poisoning.

Coquoz JL, Buchala A, Metraux JP 1998 The biosynthesis of salicylic acid in potato plants.

Conversion in plants of benzoic acid to salicylic acid and its ..

Acetyl salicylic acid (ASA) and SA that are signals for systemic acquired resistance to pathogens, inhibit the wound-induced, JA-induced, systemin-induced and oligosaccharide-elicited accumulation of proteinase inhibitors, by inhibiting the synthesis of JA (Doares et al, 1995).

Ribnicky DM, Shulaev V, Raskin I 1998 Intermediates of salicylic acid biosynthesis in tobacco.

Metraux JP 1998 The biosynthesis of salicylic acid in potato plants.

Salicylic acid is also used in the form of paint and in the form of collodion basis (10 to 17%) or as a plaster (20 to 50%) to destroy warts and corns.

Local gastrointestinal (GI) irritation of SA is more marked than ASA (acetylsalicylic acid).

Salicylic acid (SA), which is central to defense mechanisms in plants and the principal metabolite of aspirin, occurs naturally in man with higher levels of SA and its urinary metabolite salicyluric acid (SU) in vegetarians overlapping with levels in patients on low-dose aspirin regimens. SA is widely distributed in animal blood. Fasting for major colorectal surgery did not cause disappearance of SA from plasma, even in patients following total proctocolectomy. A 13C6 benzoic acid load ingested by six volunteers led, between 8 and 16 h, to a median 33.9% labeling of urinary salicyluric acid. The overall contribution of benzoic acid (and its salts) to the turnover of circulating SA thus requires further assessment. However, that SA appears to be, at least partially, an endogenous compound should lead to reassessment of its role in human (and animal) pathophysiology.

Bilateral subconjunctival haemorrhage after acetylsalicylic acid overdose.


Salicylic acid in plant defence—the players and protagonists

Penninckx IAMA, Eggermont K, Terras FRG, Thomma BPHJ, De Samblanx GW, Buchala A, Metraux J-P, Manners JM, Broekaert WF 1996 Pathogen-induced systemic activation of a plant defensin gene in follows a salicylic acid-independent pathway.

Salicylic acid (SA) is synthesised by plants in ..

Leon J, Shulaev V, Yalpani N, Lawton MA, Raskin I 1995 Benzoic acid 2-hydroxylase, a soluble oxygenase from tobacco, catalyzes salicylic acid biosynthesis.

Role of salicylic acid in plants

Plants are widely used in many indigenous systems of medicine for therapeutic purposes and are increasingly becoming popular in modern society as alternatives to synthetic medicines. , also called botanical medicine or phytomedicine is generally cheaper, accessible or readily available and more culturally acceptable to many because of the belief that they cause less side effects than some synthetic drugs (; ). Recent research efforts in drug discovery from s involve a multifaceted approach that combines botanical, phytochemical, biological and molecular techniques (). Bioactive principles are responsible for the therapeutic activities of s such as hypoglycemic, anti-diabetic, anti-oxidant, anti-microbial, anti-inflammatory, anti-carcinogenic, anti-malarial, anti-cholinergic, anti-leprosy activities etc. (). For instance, arrays of bioactive principles from diverse anti-diabetic plants have been exhaustively described elsewhere (; ). Thus, pure compounds or standardized extracts from s provide unlimited opportunities for new drug leads because of the unmatched availability and chemical diversity of bioactive principles from the plant kingdom (; ). In same manner of chemical diversity, most effective poisonous agents to humans and animals have their origin from various classes of chemical substances from plants. Some notable noxious compounds from plants are the cyanogenic glycosides (; ), myristicin (), phytohaemagglutinins or lectin (), neurotoxic s e.g., β-N-Oxalyl-L-α, β-diaminopropionic acid (ODAP) (; ), protease inhibitors, chlorogenic acid, amylase inhibitors, gossypol, goitrogens (; ), veratridines () etc.

salicylic acid found in plants like willow and ..

The dyes industry was also in the forefront in asserting intellectual property rights. Favorable patent laws play important roles in the pharmaceutical and life science industries; witness the recent scramble to patent human genes. However, they did not benefit aspirin. Bayer settled for registering a trademark for the name Aspirin. It did not patent acetylsalicylic acid, not because it would not but because it could not. The chemical was old stuff, synthesized by French chemist Charles Frederic Gerhardt back in 1853.

Role of Salicylic Acid in Plants | Annual Review of Plant …

Doares SH, Narvez-Vasques J, Conconi A, Ryan CA 1995 Salicylic acid inhibits synthesis of proteinase inhibitors in tomato leaves induced by systemin and jasmonic acid.