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Bioactive Principles from Medicinal Plants - Science Alert

Traditional uses, chemistry and pharmacology of …

Reports have showed that the exposure or ingestion of certain plant alkaloids could provoke harmful outcomes. Insects and herbivores are often repulsed by the potential toxicity and bitter taste of alkaloids. For instance, lupin alkaloids are feeding deterrents and lethal to certain species of insects, especially aphids (). Also, quinolizidine alkaloids toxicity to insects and vertebrates is attributable to the interactions of sparteine or lupanine (alkaloids) with N-acetylcholine receptors (nAChR) (sparteine or lupanine activates nAChR), Na+/K+- channels and interference with protein biosynthesis (). The anti-nutrients attributes of alkaloids are in connection with their actions in the central nervous system, which disrupt or cause inappropriate transmission of electrochemical signals. Specifically, massive intake of tropane alkaloids elicits rapid heartbeat, paralysis and in fatal case, leads to death. Likewise, high dose of tryptamine alkaloids cause staggering gate and death (). Strychnine alkaloids are used as rat poison (). The molecular configurations of some common alkaloids are shown in .

Frontiers Quinolizidine Alkaloid Biosynthesis in Lupins and Prospects for Grain Quality Improvement Plant Science

Natural Products as Sources of New Drugs over the …

Generally by default it is assumed that alkaloids are in plants to protect the plant from attack by predators, but given the strong possibility of the quinolizidine alkaloids actively controling the activity of LDC it is conceivable that the quinolizidine alkaloids are being produced to control other LDC mediated biosynthetic pathways, like the biosynthesis of chlorophyll for instance.

Read "Lysine Decarboxylase Catalyzes the First Step of Quinolizidine Alkaloid Biosynthesis and Coevolved with Alkaloid Production in Leguminosae" on DeepDyve…

As opposed to the cell culture biosynthetic research this root feeding of phenylalanine proved that if a plant is given this precursor in its water supply it can absorb it and incorporate it into the quinolizidine alkaloids.

Traditional uses, chemistry and pharmacology of Croton …