Piracetam - American Chemical Society
Piracetam improves the function of the neurotransmitter Acetylcholine via Nuscarinic Cholinergic (ACh) receptors, which are implicated in memory processes. It may have an effect on glutamate receptors, which are involved with learning and memory processes. It is also thought to increase cell membrane permeability. It also may exert its global effect of brain neurotransmission via modulation of ion channels. While in the brain, it appears to increase the synthesis of cytochrome b5, which is a part of the electron transport mechanism in mitochondria. But in the brain, it also increases the permeability of the mitochondria of some intermediaries of the Krebs Cycle.
03/06/2004 · Piracetam from 2-Pyrrolidone Hi, ..
Piracetam was first synthesized in 1964 by scientists at the Belgian pharmaceutical company UCB, led by Corneliu E. Giurgeal, who were struck by its ability to boost mental functioning in healthy individuals along with its apparent safety, Fiurgea coined the term nootropics to describe it and similar substances.
Corneliu E. Giurgea, a Romanian psychologist and chemist formulated and synthesized Piracetam in 1964. It is a compound known to conform to the characteristics of both a nootropic and neuroprotective agent. It is prepared by condensing 2-pyrrolidinone with ethyl chloroacetate which then is converted into an amide with ammonia.