Choline | Linus Pauling Institute | Oregon State University

Glossary | Linus Pauling Institute | Oregon State University
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Achlorhydria the absence of hydrochloric acid in gastric juice

Chemistry and function, how does it work?
Once produced, acetylcholine is stored in brain cells and released into thesynaptic cleft upon stimulation. When released into the synaptic cleft, the enzymeacetylcholinesterase breaks acetylcholine back down into choline and acetyl. InAlzheimer’s disease, there is a shortage of acetylcholine, and one of the waysdoctors have tried to increase the levels of this neurotransmitter is by prescribingdrugs, such as tacrine and , that inhibit the enzyme acetylcholinesterase. Analternative to these drugs, a Chinese herbal extract called huperzine A, can alsoinhibit this enzyme. Galantamine is now available without a prescription.

Acetylation the addition of an acetyl group (-COCH 3) group to a molecule
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2. Effects of ethanol and pantothenic acid on brain acetylcholine synthesis.
Rivera-Calimlim L, Hartley D, Osterhout D.
Department of Pharmacology, University of Rochester, School of Medicine and Dentistry
Br J Pharmacol. 1988 Sep;95(1):77-82. PMID: 3219477 []

Choline / ˈ k oʊ l iː n / is a water-soluble vitamin-like essential nutrient
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Drugs and medications that interfere
Medicines taken by millions for depression, asthma, allergies, and other conditions may raise that risk for dementia. The drugs are known as anticholinergics. They work by blocking the brain chemical called acetylcholine, which is crucial for memory. Many over-the-counter and prescription drugs work in this way, ranging from the antidepressant Paxil (paroxetine) to the allergy drug Benadryl (diphenhydramine) to the motion sickness remedy Dramamine (dimenhydrinate).

B Vitamins and Coenzymes supplements - Ray Sahelian
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