Defining chemical reactions of the polyphenol class

We also found that administration of a soy isoflavone supplement containing genistein reduces ..

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You can read more from IMMY (Immuno-Mycologics, Inc.), the manufacturer of the Quest test, at this description of their antibody test. There is a somewhat better description provided for the Candida test. "Immunodiffusion tests are used for the detection of precipitating antibodies (primarily of the IgG and IgA classes) against antigens of C. albicans. The presence of precipitating antibodies indicates active or recent infection."

Polyphenols: food sources and bioavailability

Candida can be caused to turn from yeast to fungal mode by stimulation of estrogens. This includes stimulation by genistein, the primary isoflavone found in soy. There MAY be a connection to GS in that two of the three UGT enzyme systems that work slow in us process estrogens, including genistein, meaning that they probably last in the system a lot longer than in other people. Estrogens also make fungal candida more able to survive higher and lower than normal temperatures in the body. Coumarins are also protective to candida, and are processed more slowly by those with GS.

Microbial virulence is generally considered to be multifactorial with infection resulting from the sum of several globally regulated virulence factors. Estrogen may serve as a signal for global virulence induction in Candida albicans. Nonsteroidal estrogens and estrogen receptor antagonists may therefore have interesting effects on yeast and their virulence factors. Growth of C. albicans was monitored by viable plate counts at timed intervals after inoculation into yeast nitrogen broth plus glucose. To determine if increased growth of yeast in the presence of estradiol was due to tyrosine kinase-mediated signaling, we measured growth in the presence of genistein, estradiol or genistein plus estradiol and compared these conditions to controls, which were not supplemented with either compound. Unexpectedly, genistein stimulated growth of C. albicans. In addition, genistein was found to increase the rate of germination (possibly reflecting release from G(0) into G(1) cell cycle phase) and also increased Hsp90 expression, demonstrated by a dot blot technique which employed a commercial primary antibody detected with chemiluminescence with horseradish peroxidase-labeled secondary antibody. These biological effects may be attributable to genistein's activity as a phytoestrogen. In contrast, nafoxidine suppressed growth of Candida and mildly diminished Hsp90 expression. This study raises the possibility of receptor cross-talk between estrogen and isoflavinoid compounds, and antiestrogens which may affect the same signaling system, though separate targets for each compound were not ruled out.