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A Ruthenium-catalyzed, atom-economical synthesis of nitrogen heterocycles …

The parent molecules' molecular formula is C 3 H 3 N 3

The monography describes examples of the application of microbial technologies for obtaining of derivatives from a series of nitrogen heterocycles (saturated nitrogen heterocycles, azaarenes and quinolones). It is proposed alternative ways for synthesize substances that are difficult to obtain by the methods of organic chemistry. Microbial technologies of synthesis of organic compounds may find out a practical application in the production of various drugs.

Synthesis of N -Heterocycles - Organic chemistry

In summary, we have developed a new atom-economical, domino synthesis of nitrogen heterocycles. It was shown that both sulfonamides and carbamates are compatible with the overall process and participate in the domino reaction to form heterocycles via exo and endo type cyclizations. Given the inherent availability of propargyl alcohols through classical alkynylation chemistry, this catalytic domino reaction remarkably disconnects the α-position of a substituted nitrogen heterocycle to a triple bond (of a propargyl alcohol) in a retrosynthetic manner, further increasing the arsenal of possible chemical approaches to the synthesis of alkaloids. Further investigations on this process are underway and will be reported in due course.

Ryan R. Walvoord was born in 1986 in the small town of Williamson, NY. He received a B.S. in Chemistry from the Rochester Institute of Technology in 2007, where he performed undergraduate research in the laboratories of Professor Christina G. Collison. In the same year, he began his graduate studies at the University of Pennsylvania under the guidance of Professor Marisa C. Kozlowski. His research in the Kozlowski group has focused on the synthesis and chemistry of arylnitromethanes, as well as the spectroscopic investigation of hydrogen bonding using colorimetric sensors.


Aerobic Copper-Catalyzed Organic Reactions - …

Nitrogen-containing heterocycles are ubiquitous subunits of a variety of biologically active substances. Although this has spurred the development of a considerable body of synthetic methods aimed at their efficient preparation, there is a continuous need for new processes which can produce functionalized azacyclic substructures which maximize atom economy.

Allen was born in 1984 in Kutztown, Pennsylvania

The Ruthenium catalyzed, atom-economical domino redox isomerisation/cyclization of tethered aminopropargyl alcohols is reported. This process displays a broad scope and functional group tolerance. Furthermore, it presents a novel retrosynthetic disconnection linking simple and easily available, linear propargyl alcohols with added-value nitrogen heterocycles in a single catalytic step.

Organic Letters (ACS Publications)

Abstract:
This work focuses on the synthesis and the modification of mesoporous silica SBA-15 using in-situ polymerization of polypyrrole. In order to study the effect of polypyrrole contents on the structural, textural and dye adsorption properties, several polypyrrole contents were dispersed and analyzed by various techniques such as X-ray diffraction (XRD), nitrogen sorption at 77 K, thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR) and scanning electronic microscopy (SEM). The obtained materials were tested for the removal of cationic and anionic dyes. The effect of pH, contact time, adsorbent dose, and initial dye concentration were investigated and discussed in terms of adsorption efficiency. The obtained results show that the adsorption efficiency of MO dye is preferably carried out by the nanocomposites PPY/SBA-15(50%) containing higher polypyrrole content. Whereas, the adsorption of MB is oriented by the parent material SBA-15 and the nanocomposite PPY/SBA-15(1%) containing lower content of polypyrrole. The experimental data were verified by the Langmuir and Freundlich isotherms, and the kinetic data were fitted by pseudo-first-order and pseudo-second-order models. The obtained results showed that the adsorption of the both dye by nanocomposite PPY/SBA-15 followed Langmuir adsorption isotherm models and pseudo-second-order kinetics. The adsorbed amounts recorded for MO and MB dyes are 41.66 mg/g and 58.82 mg/g, respectively.