Multistep Synthesis - Michigan State University
But RBW did seem to be well aware of the Separation and Purification problem, even if he didn’t have to do it himself. RBW’s undergrad thesis mentions the mathematical demon of sub-100% yields that plagues multistep syntheses (even 0.99^n hurts you after small n). RBW did a lot of work on peptide coupling to improve yields and simplify separations. RBW was eager to adopt and promote HPLC as a method to separate and purify product mixtures. And, of course, he was keen on crystallization as a method of separation and purification. He would tell his students to “Keep scratching!” He even named his daughter Crystal.
How to approach synthesis problems | Organic Chemistry …
Across disciplines, technologies and social sciences: Engaging on thinking how crossing disciplinary borders enables us to approach societal issues in a more comprehensive mode. What are the links between technologies and social sciences and how anthropology is fundamental to the social use of technologies?; Collaborative research: Introduction to methods incorporating different disciplines and distinct approaches, in order to organize research under different perspectives; A first approach to a village - its territory: Introductory fieldwork visits to the villages to be studied, in order to have a first sense of the realities we can observe. Under the notion of ‘territory’, we can start to discuss what happens in that place; Different layers of a map, mapping: Geography, urbanism, social and spatial structure’ – research on different subjects found in the villages where field work is done. How in the same place, a village, we find different realities and many topics to analyze, and how we can build different maps focusing on different aspects; Population, social world, social use of space: Engagement with ethnographic methods to discuss what are the meanings and contexts of the realities observed. Space and its use as translating the social universe of the studied villages; Constraints and problems, developmental matters: Observation and analysis of societal issues present in the villages - from water management to electrical connections, education, health or agricultural production. Cross these analyses with the discussions on ethnographic methodology to better understand the social and cultural contexts of the issues; Creative brainstorming – problems and solutions: Engaging with the recent anthropological research on infrastructure and development, in order to broaden a creative approach to the research projects using different media of registering and thinking: drawings, maps, photographs, film.
One of the most challenging aspects of learning organic chemistry is devising sequences of reactions that will lead from a designated starting compound to a desired product compound. This problem is an introduction to the planning of multistep syntheses. For use, you have six reactant compounds ( through ); and eight reagents ( through ), shown below.
Following these lists, five multistep syntheses are outlined. For each of these, certain reactants or reagents must be identified by entering an appropriate letter or number in designated answer boxes.