Mambog, Mitragyna speciosa, KRATOM: Philippine …

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8 factor analysis of kratom performed by Dr. …

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• Synthetic and Receptor Signaling Study / Mitragynine as Molecular Framework for Opioid Receptor Modulators: Study describes the first receptor-level functional characterization of mitragynine and related natural alkaloids at the human mu-, kappa-.

Total synthesis of the opioid agonistic indole alkaloid mitragynine and the first total syntheses of 9-methoxygeissoschizol and 9-methoxy-Nb-methylgeissoschizol.

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It would not likely be simple or inexpensive to extract and concentrate the MG or 7-OH- MG from kratom leaves, and it would require sophisticated equipment and chemistry training, but it would be theoretically possible. In Southeast Asia where the raw material is plentiful and there are many clandestine laboratories for synthesizing substances for abuse, kratom-derived products have not been a target, likely due to the apparently low abuse liability of mitragynine and limited euphoriant-like effects produced by the product. Furthermore, in contrast to the effects of increasing the dose of substances of high abuse potential (e.g., prototypic opioids, stimulants and sedatives), increasing the dose of kratom is more likely to produce undesirable gastrointestinal effects, constipation, and lethargy, and little additional mood enhancement.

Feb 22, 2004 · Studies on the Synthesis and Opioid Agonistic Activities of Mitragynine-Related Indole ..

Kruegel A.C., Gassaway M.M., Kapoor A., Váradi A., Majumdar S., Filizola M., Javitch J.A., Sames D. (2016). Synthetic and receptor signaling explorations of the mitragyna alkaloids: Mitragynine as an atypical molecular framework for opioid receptor modulators. Journal of the American Chemical Society 138(21):6754-64.