Fatty acid synthesis - Wikipedia
discovered the essentiality of thelong-chain polyunsaturated fatty acids (linoleic and linolenic acids) ().
Anderson RJ reported the presence of inositol in lipids of tubercle bacilli ().
First demonstration of the biosynthesis of vitamin A from
Fatty acid synthesis is the creation of fatty acids ..
demonstrated that nearly allphosphatidylserine and a minimum of 70% of phosphatidylethanolamine is on theinside surface of the human erythrocyte membrane, thus "presenting a strongevidence for an asymmetric arrangement of phospholipids" ().
First demonstration of an inhibition of sterol biosynthesis (HMG-CoA reductaseactivity) by oxygenated derivatives of cholesterol in cultured mammalian cells ().
For the first time, the existence of polyunsaturated fatty acids was reported inmarine bacteria ().
described for the first time the synthesis of mixed acidtriglycerides ().
Description of the specific presence of fatty acids in the depot fats ofruminants in contrast to their absence in non-ruminants ().
The "phospholipid effect" discovered in 1953 is now attributed to aphosphoinositide in connection with phosphatidic acid metabolism(phosphatidylinositol cycle) ().
Barber JM et al.
Regulation of Cholesterol and Fatty Acid Synthesis
3. Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem. 2002 Dec 27;277(52):50230–6.
In addition to lipid metabolism, this signaling mechanism ..
described for the first time the synthesis of a naturalneutral lipid, tributyrin, by the direct esterification of glycerol and butyricacid ().
Lipid metabolism - What is Life HOME
Thus, oxidized triacylglycerol monomers include molecules containing different oxygenated groups, mainly hydroxy, keto, and epoxy, as well as short-chain fatty acyl and short-chain n-oxo fatty acyl groups as the main products (Chang SS et al., JOACS 1978, 55, 718; Velasco J et al., Eur J Lipid Sci Technol 2004, 106, 728). It is noteworthy that a polyunsaturated fatty acid (DHA) was shown to be more stable to oxidation when located at the sn-2 position of triacylglycerol compared to sn-1(2) (Wijesundera C et al., JAOCS 2008, 85, 543).
The identification of the products of fatty acid autoxidation often provides valuable mechanistic information on the extent of the peroxidative injury.
Lipids and their role in metabolism
of the synthesisof oleic acid ().
Klenk E identified sphingomyelin as the stored phospholipid in cells frompatients with Niemann-Pick disease ().
Von Euler US identified a lipid-soluble substance from semen which stimulatesuterine smooth muscle contraction and named it prostaglandin ()
The lipid fraction of the coffee bean - SciELO
About 40% of the bodies caloric intake is derived from lipids and almost all of these calories come from fats, the . The fatty acid composition in terms of saturation (oxidation forms) is not uniform but varies with the origin. Plant fats contain more polyunsaturated fatty acids and animal fats contain more saturated fatty acids as well as cholesterol. Polyunsaturated fats are essential for humans because animals are not able to synthesize those on their own. Most lipids, however, have metabolic functions contributing to membrane structures and signaling. (C20:4) is a fatty acid which plays a central role as precursor for prostaglandin synthesis. Phospholipids are synthesized from diacylgycerolphosphate, a negatively charged phospholipid precursor and signaling molecule itself, carrying various hydrophilic and/or charged headgroups that determine the surface charge and chemical properties of biological membrane surfaces.