Mechanism of the initial reaction of formaldehydewith DNA.
Patch tests performed with formaldehyde challenge concentrations of< 1% formaldehyde resulted in positive reactions in about 2% of allpatch-tested patients throughout the world.
(1979) Reaction of formal-dehyde with calf-thymus nucleohistone.
These react with OH radicals and ozone toform formaldehyde and/or other aldehydes as intermediates in a seriesof reactions that ultimately lead to the formation of carbon monoxideand dioxide, hydrogen, and water (Zimmermann et al., 1978; Calvert,1980).
A simple colour reaction for the identification of urea formalde-hyde resins and diisocyanates, carried out on the surface of wood-basedpanels, has been described by Schriever (1981).
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188.8.131.52.1 Allergic reaction following the dental use of paraformaldehyde Adverse reactions have been reported following the use of rootcanal filling materials containing paraformaldehyde.
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184.108.40.206 Systemic sensitization A case report has been described involving an anaphylactic shockreaction after accidental iv application of formaldehyde duringhaemodialysis treatment due to formaldehyde remaining in the equipmentafter disinfection.
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Allergic reactions to cosmetics containing formaldehyde as a pre-servative, especially shampoos, are unusual (Eckardt, 1966) and appearmostly among those who have been sensitized by occupational exposure.
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An allergic contact dermatitis reaction was provoked by a dose offormaldehyde of 0.25 µg/cm2 skin (challenge dose: 50 µg/cm2 with0.5% percutaneous penetration).
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Patch tests performed with formaldehyde challenge concentrations of1% or less resulted in positive reactions in about 2% of all patientstested throughout the world; higher formaldehyde challenge concen-trations may be irritant (Anon., 1987).
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Formaldehyde solution is a primary skin-sensitizing agent inducingallergic contact dermatitis (Type IV, T-cell mediated delayed hypersen-sitivity reaction); it may induce immunological contact urticaria(Type I, perhaps IgE mediated, immediate hypersensitivity reaction).
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Marzulli & Maibach (1973) reported that one of 5 sen-sitized volunteers reacted, under controlled conditions, to a challengeconcentration of 0.01% formaldehyde.