Other Nanomaterial-Based Clinical Applications
130. Wang YXJ, Quercy-Jouvet T, Wang HH, Li AW, Chak CP, Xuan S, Shi L, Wang DF, Lee SF, Leung PC, Lau CBS, Fung KP, Leung KCF. Efficacy and durability in direct labeling of mesenchymal stem cells using ultrasmall superparamagnetic iron oxide nanoparticles with organosilica, dextran, and PEG coatings. 2011;4:703-15
Nanomaterials are being put to other clinical uses
136. Lee H, Yu MK, Park S, Moon S, Min JJ, Jeong YY. . Thermally cross-linked superparamagnetic iron oxide nanoparticles: synthesis and application as a dual imaging probe for cancer in vivo. 2007;129:12739-45
Stem cells hold great promise for the treatment of multiple human diseases and disorders. Tracking and monitoring of stem cells after transplantation can supply important information for determining the efficacy of stem cell therapy. Magnetic resonance imaging (MRI) combined with contrast agents is believed to be the most effective and safest non-invasive technique for stem cell tracking in living bodies. Commercial superparamagnetic iron oxide nanoparticles (SPIONs) in the aid of transfection agents (TAs) have been applied to labeling stem cells. However, owing to the potential toxicity of TAs, more attentions have been paid to develop novel SPIONs with specific surface coating or functional moieties which facilitate effective cell internalization in the absence of TAs. This review aims to summarize the recent progress in the design and preparation of SPIONs as cellular MRI probes, to discuss their applications and current problems facing in stem cell labeling and tracking, and to offer perspectives and solutions for the future development of SPIONs in this field.
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Schematic illustration of the silica nanoporous particle-supported lipid bilayer, depicting the disparate types of therapeutic and diagnostic agents that can be loaded within the nanoporous silica core, as well as the ligands that can be displayed on the surface of the nanoparticle. Reproduced with permission from ref. .
Cyanine5.5 NHS ester - Lumiprobe
Integrating multiple functionalities into a single nanoparticle (NP) is an important strategy to design hybrid materials for advanced applications. Recently, there has been a growing interest in the synthesis of heterodimeric metal–metal oxide NPs comprising nonprecious metal oxides owing to their unique magnetic, optical, and catalytic properties. The production of shape-controlled heterometallic NPs consisting of Pt and nonprecious metal oxides is crucial to demonstrate the composition–property relationship of NPs. Herein, a facile one-pot approach for the controlled synthesis of dumbbell-like Pt–Fe3O4–MnOx and dendritic Pt–MnOx NPs were reported. The key to the success of this synthesis is in changing the quantity of Fe(CO)5 additive to control the reaction kinetics. In the absence of Fe(CO)5, dendritic Pt–MnOx NPs were synthesized through the assembly of small seed NPs. On the other hand, dumbbell-like Pt–Fe3O4–MnOx NPs were obtained in the presence of Fe(CO)5 through controlling the nucleation and growth of Fe and Mn on the Pt NPs, followed by air oxidation. Compared to a Pt/graphene oxide (GO) catalyst, dumbbell-like Pt–Fe3O4–MnOx NPs on GO showed an enhancement of specific activity toward the oxygen reduction reaction owing to the compressive-strain effect exerted on the Pt lattice.
Cyanine5.5 NHS is far-red / near-infrared amine-reactive dye.
Ruoslahti . described self-amplifying tumor homing nanoparticles . The system was based on a CREKA peptide that not only recognizes clotted plasma proteins around tumor vessel walls or tumor stroma but also induces localized tumor clotting [-]. Fluorescein-labeled peptides, including the sulfhydryl group of the single cysteine residue, were coupled to amino dextran-coated iron oxide nanoparticles (CREKA-SPIO), and nanoparticles with at least 8,000 peptide molecules per particle were used for experiments. To reduce reticuloendothelial system (RES) uptake, a major obstacle to the homing of the nanoparticles, chelated Ni2+-liposome or liposomes as potential decoy particles were introduced prior to CREKA-SPIO injection. CREKA-SPIO treatment after pretreatment with the decoy particles displayed primary localization in the tumor vessels, and fewer particles were seen in the liver. The tumor-targeted nanoparticles were distributed along a meshwork in the clots, presumably formed by fibrin, suggesting that the nanoparticles infiltrated the depths of the clots. The tumor magnetization was quantitatively analyzed using a superconducting quantum interference device (SQUID), revealing that heparin injection prior to injection of CREKA-SPIO reduced the tumor accumulation of nanoparticles by >50% by eliminating intravascular clotting, although the treatment series did not considerably reduce the number of vessels. Thus, binding of CREKA-SPIO to tumor vessels did not require clotting activity, but intravascular clotting attracted more nanoparticles to the tumor, suggesting that tumor targeting was amplified.
UVO-Cleaner Studies Using Jelight Company Inc. Products
Title of Talk: Synthesis and characterization of gold nanoparticles supported on two different metal oxides prepared by impregnation with ionic exchange