The effect of pH on enzyme actvity - pH and enzymes - …

The pH of a solution can have several effects of the structure and activity of enzymes

Chemistry for Biologists: Enzymes

This biochemical similarity between the χ-modified RecBCD and RecBC enzymes implies that recognition of χ results in a dissociation or functional inactivation of RecD subunit and lends support to the hypothesis that interaction with χ results in ejection of the RecD subunit.

Which of the following enzymes would digest a fat

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N2 - Background - Cerebral blood flow is tightly coupled to neuronal metabolic activity, a phenomenon referred to as functional hyperemia. The mechanisms underlying functional hyperemia in the brain have been extensively studied, but the link between neuronal activation and nutritive blood flow has yet to be defined. Recent investigations by our laboratory and others have identified a potential role for astrocytes as an intermediary cell type in this process. Summary of Review - This short review will develop the hypothesis that cytochrome P450 epoxygenase activity in astrocytes catalyzes formation of epoxyeicosatrienoic acids (EETs), which act as potent dilators of cerebral vessels and are released in response to glutamate receptor activation within astrocytes. Neuronal activity stimulates release of arachidonic acid from the phospholipid pool of astrocytic membranes. We provide evidence that the arachidonic acid released on stimulation of glutamate receptors within astrocytes is metabolized by cytochrome P450 2C11 cDNA enzymes into EETs. Conclusions - The EETs thus formed will be released and activate K+ channels, increase outward K+ current, and hyperpolarize the plasma membrane. The resulting membrane hyperpolarization inhibits voltage-gated Ca2+ channels and leads to arteriolar dilation, thereby increasing regional nutritive blood flow in response to neuronal activity.

Mutations in the Lysosomal Enzyme–Targeting Pathway …

This biochemical similarity between the χ-modified RecBCD and RecBC enzymes implies that recognition of χ results in a dissociation or functional inactivation of RecD subunit and lends support to the hypothesis that interaction with χ results in ejection of the RecD subunit.",}

25/02/2010 · Original Article