Fludeoxyglucose (18F) - Wikipedia

Synthesis of (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (2)
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Simple synthesis of F-18-labeled 2-fluoro-2-deoxy-D ..

Glucosamine (2-amino-2-deoxy-D-glucose) is a highly attractive scaffold for a glucosyl ligand, because the amine acts both as a potential coordination site and as a useful target for further functionalization. Furthermore, there is much evidence in the literature which suggest that N-functionalized glucosamines show activity with GLUTs (glucose transporters) and hexokinases, the enzymes that are most closely associated with the metabolism of FDG, even when the functional group is large (, ). For example, Yang et al. reported that ethylenedicysteine-deoxyglucose (EC-DG) as an N-functionalized glucosamine, shows activity with hexokinases. Their findings suggested that hexokinase-catalyzed phosphorylation had occurred with EC-DG, 2-deoxy-D-glucose, 2-fluorodeoxyglucose (FDG), and glucose. Whether EC-DG and 2-deoxy-D-glucose use different glucose transporters,both of them need to be further investigated (). In addition, it has been confirmed that there are at least two mechanisms for the cellular processes of glucosamine. The first mechanism resembles the cellular process mechanism of a glucose transporter system. In the second mechanism, glucosamine enters cells and forms glucosamine-6-phosphate directly in the additional transcriptional pathways (-). Lots of 99mTc-labeled glucose and D-glucosamine derivatives have been synthesized in order to develop one subrogate in SPECT for [18F]-FDG in PET (, , , , , -).

Efficient microscale synthesis of [18 F]-2-fluoro-2-deoxy-d-glucose
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Improving the yield of 2- [18 F]fluoro-2-deoxyglucose using ..

Volkow, N. D., Tomasi, D., Wang, G. J., Fowler, J. S., Telang, F., Goldstein, R. Z., Alia–Klein, N., et al. (2011). Positive emotionality is associated with baseline metabolism in orbitofrontal cortex and in regions of the default network. , (8), 818–825. doi:10.1038/mp.2011.30 Positive emotionality (PEM) (personality construct of well–being, achievement/motivation, social and closeness) has been associated with striatal dopamine D2 receptor availability in healthy controls. As striatal D2 receptors modulate activity in orbitofrontal cortex (OFC) and cingulate (brain regions that process natural and drug rewards), we hypothesized that these regions underlie PEM. To test this, we assessed the correlation between baseline brain glucose metabolism (measured with positron emission tomography and [(18)F] fluoro–deoxyglucose) and scores on PEM (obtained from the multidimensional personality questionnaire or MPQ) in healthy controls (n=47). Statistical parametric mapping (SPM) analyses revealed that PEM was positively correlated (P(c)

A short synthesis of 2-deoxy-2-fluoro-D-glucose.
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Maximum yields of labeling (~93%) could be achieved when the reactions were carried out at biological pH, but cleavage of the glucosamine moiety was observed when the labeling was carried out in alkaline condition. Although, we reached to better resolutions, but the expanding of the peaks may be took place because of the presence of α,β-anomeric carbons in compounds 1 and 2. However, these complexes were stabled for 7 hours in 1 N of PBS as well as human serum at 37 ºC ().

Sep 15, 1986 · A short synthesis of 2-deoxy-2-fluoro-D-glucose
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