phenethyl acetate, 103-45-7 - The Good Scents Company
However, while a relatively large oral dose of MEK (1.4 ml for 3 days) to rats increased the amount of ethanol- and phenobarbital-inducible cytochromes P-450 (P-450IIE1 and P-450IIB, respectively) (Raunio et al., 1990), inhalation exposure of rats to 1770 mg MEK/m3 (600 ppm), 10 h/day for 7 days, caused only marginal effects on microsomal cytochrome P-450 activities in the liver (Liira et al., 1991).
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CCl4 hepatotoxicity in rats has been found to be potentiated by induction of the P-50IIE1 isozyme with ethanol and the injury was most marked in the perivenous liver cells where the expression of induction was the highest (Lindros et al., 1990).
Ko I-Y, Park SS, Song BJ, Patten CH, Tan Y, Hah YC, Yang CS, & Gelboin HV (1987) Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines.
Methyl ethyl ketone (EHC 143, 1992) - IPCS INCHEM
Ingestion of ethanol (0.8 g/kg) combined with an inhalation exposure to MEK (590 mg/m3, 200 ppm) inhibited the oxidative metabolism of MEK and led to a marked increase in the blood concentration of MEK (Liira et al., 1990b).
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However, a daily dose of 1.4 ml MEK per kg for 3 days increased the amounts of ethanol- and phenobarbital-inducible cytochromes P-450 (P-450 IIEI and P-450 IIB) (Raunio et al., 1990).
Anyone please suggest the lab scale synthesis of 1-ethyl …
It is likely that 2-butanol, like ethanol (Mezey, 1976), inhibits oxidative pathways of drug metabolism and thus inhibits the hydroxylation step leading to 3-hydroxy-2-butanone.
Please suggest the lab scale synthesis of 1 ..
Conversion factors for various solvents (ppm --> mg/m3) acetone 2.38 2-butanol 3.03 n-butanol 3.03 2-butoxyethanol 4.83 butyl acetate 4.75 cyclohexane 3.44 DBP 11.38 DCB 6.01 ethanol 1.88 2-ethoxyethanol 3.68 ethyl acetate 3.6 ethyl butyl ketone 4.6 n-hexane 3.52 isobutanol 3.03 isopropanol 2.45 2-methoxyethanol 3.11 methyl acetate 3.6 methyl butyl ketone 4.1 methyl ethyl ketone 2.95 methyl isobutyl ketone 4.1 methylene chloride 3.48 toluene 3.75 trichloroethane 5.46 trichloroethylene 5.38 white spirit 1.75 xylene 4.34 From: Clayton & Clayton (1981) and Weast (1986)
[2-(2-Butoxyethoxy)ethyl] acetate CAS 124-17-4 | 821014
MEK has been reported to be a metabolic end product of natural gas (methane 88%, ethane 5%, propane 5%, isobutane 2% with traces of tert-butyl mercaptan and methyl acrylate) inhaled for 2 h by ICR mice (Tsukamoto et al., 1985a).
CAS 124-17-4, pH 3 - 4 (50 g/l, H₂O, 20 °C)
Another method (Fisk, 1986) either directly purges MEK and other organic compounds from a water/solid material slurry held at an elevated temperature or purges a methanol extract of the solid material at an elevated temperature.