Aminostatic hypothesis - Related Articles - Citizendium
The energostatic hypothesis is based on the idea that, because the controls eating, it seems reasonable that might be triggered by a decrease in the availability of energy for the brain itself.
Aminostatic hypothesis/Related Articles
Other researchers have proposed that cells of the proximal small intestine, the , may be more appropriately placed to sense incoming metabolic load: This area of the small intestine also has vagal afferent fibres and the mucosal terminals are responsive to chemical stimuli, including ATP. However the role of enterocytes in the energostatic hypothesis has not been proven and the search for the ultimate sensor of energy availability through metabolism continues.
Some research has shown that other substances must be acting to control feeding as well as glucose. One factor that has been widely studied is insulin which was used alongside glucose to determine its effectiveness as a short-term regulator of appetite. One such study compared the use of a glucose load and a glucose-plus-insulin load of determining utilization of energy and feeding behaviour. The results suggested that many different nutrients are required in energy balance and not just the control of glucose is involved in the short-term feeding patterns. This study was one of the first to propose that the energostatic hypothesis was related to more than glucose loading and expenditure.