Amine synthesis by nitro compound reduction

| Custom Synthesis, Isotope Labeled Internal Standards, Online Catalog: BDG Synthesis
Photo provided by Flickr

Categories: N-H Bond Formation > Reduction of nitro compounds

N2 - One of the components of the "chalcone lab", namely, the individualized, three-step synthesis of the 3,5-diarylisoxazole followed by isomer determination using 13C NMR or mass spectroscopy is presented as an expansion of the one-step chalcone synthesis. The two added steps in the three-step synthesis involve addition of bromine to the double bond of the chalcone followed by conversion of the dibromide to the isoxazole by reaction with hydroxylamine. The chalcone dibromide is prepared by addition of bromine to the chalcone in acetic acid. The dibromide is heated with hydroxylamine hydrochloride in the presence of KOH for 5-10 minutes to give the isoxazole. The predictable fragmentation pattern that is observed in the mass spectra of 3,5-diarylisoxazoles can also be used to determine which isoxazole isomer is in hand.

HOW TO SYNTHESIS 1 2-DIBROMIDE. We’ve successfully helped hundreds of students around the world and try to keep it that way
Photo provided by Flickr

Ethylene definition, containing the ethylene group. See more.

One of the components of the "chalcone lab", namely, the individualized, three-step synthesis of the 3,5-diarylisoxazole followed by isomer determination using 13C NMR or mass spectroscopy is presented as an expansion of the one-step chalcone synthesis. The two added steps in the three-step synthesis involve addition of bromine to the double bond of the chalcone followed by conversion of the dibromide to the isoxazole by reaction with hydroxylamine. The chalcone dibromide is prepared by addition of bromine to the chalcone in acetic acid. The dibromide is heated with hydroxylamine hydrochloride in the presence of KOH for 5-10 minutes to give the isoxazole. The predictable fragmentation pattern that is observed in the mass spectra of 3,5-diarylisoxazoles can also be used to determine which isoxazole isomer is in hand.

Monomer-Polymer & Dajac Laboratories Inc
Photo provided by Flickr

AB - One of the components of the "chalcone lab", namely, the individualized, three-step synthesis of the 3,5-diarylisoxazole followed by isomer determination using 13C NMR or mass spectroscopy is presented as an expansion of the one-step chalcone synthesis. The two added steps in the three-step synthesis involve addition of bromine to the double bond of the chalcone followed by conversion of the dibromide to the isoxazole by reaction with hydroxylamine. The chalcone dibromide is prepared by addition of bromine to the chalcone in acetic acid. The dibromide is heated with hydroxylamine hydrochloride in the presence of KOH for 5-10 minutes to give the isoxazole. The predictable fragmentation pattern that is observed in the mass spectra of 3,5-diarylisoxazoles can also be used to determine which isoxazole isomer is in hand.

Triphenylphosphine 603-35-0 | TCI America
Photo provided by Flickr