Facial feedback hypothesis - Wikipedia

These experiments led to the formulation of the Chemoaffinity hypothesis

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An abundance of experiments have been performed toinvestigate the function of the PI3K/AKT pathway in regulatingtumor angiogenesis, and so the mechanism of angiogenesis regulatedby the PI3K/AKT pathway is, to a certain extent, clear. However,the association between angiogenesis and SGK3 remains unclear. Asthey are downstream mediators of the PI3K/PDK1 signaling pathway,AKT and SGK3 have certain similar substrates and share certaintargeting molecules. Thus, we hypothesize that a strong signalingconnection may exist between angiogenesis and SGK3, contributing totumor malignant transformation.

Overall, the imagination is one of the bases for science, as scientists use it to create concepts for hypotheses and experiments to test in reality.

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(Wikipedia, 2002) The hypothesis purposes that 540 million years ago during the Neoproterozic, a meter thick of ice covered the oceans and glaciers the continents for 100 million years.

Science is a field that utilizes the human imagination, the unbiased testing of hypotheses, and paradigms in order to understand the natural world.

In conclusion, the mechanism of SGK3 in oncogenesisis, to a certain extent, clear. However, its role in malignanttransformation, particularly in angiogenesis, remains to beelucidated. Based on the present datum, detailed characterizationof any role of SGK3 in the promotion of angiogenesis via CXCR4 andGSK3-β, the association between SGK3 and VEGF, and the exactmechanisms behind this are required.

It was natural for humanity to be curious about its surrounding and try to formulate ways on how to explain everyday phenomenon.

African clawed frog : Wikis (The Full Wiki)

Although X. laevis does not have the short generation time and genetic simplicity generally desired in genetic , it is an important model organism in . X. laevis takes 1 to 2 years to reach and, like most of its genus, it is . However, it does have a large and easily manipulable . The ease of manipulation in embryos has given them an important place in historical and modern developmental biology. A related species, , is now being promoted as a more viable model for genetics. used X. laevis for his famous experiments describing the development of the visual system. These experiments led to the formulation of the .

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Thus the study, which took place in Paranal, Chile using the VLT telescope, collected information about how old the stars were and where they were located in order to see if the theory, that the milky way was created from the inside out....

Apr 17, 1994 · The Chemoaffinity hypothesis states ..

Since PI3K/AKT plays an important role in tumorangiogenesis, we hypothesize that SGK3, as a downstream target ofPI3K and functionally parallel to AKT, may also be involved in themalignant transformation of tumors by promoting angiogenesis. Ithas also been reported that CXCR4 and GSK3-β, both downstream ofSGK3, may also have potential capacity in angiogenesis (,). Thesefacts demonstrated the potential role of SGK3 in promotingangiogenesis and is evidence that confirms our hypothesis ().