Rosuvastatin to Prevent Vascular Events in Men and …

Lovastatin, a compound isolated from Aspergillus terreus, was the first statin to be marketed.

ChiraTecnics - Chiral Solutions for a Better Life

With a world-class chemistry team, effective communications, and highly experienced management, Evershine have developed Pitavastatin (Pitavastatin Calcium), Rouvastatin (Rosuvastatin Calcium), , Valacyclovir, Epalrestat and so on and already supplied the intermediates in commercial quantity.

Evershine is growing rapidly to meet the needs of our clients.

ChiraTecnics was founded in 2009 by Prof

Whilst the company still offers this portfolio to clients, it now mainly focuses on custom synthesis programmes to support medicinal chemistry and drug discovery projects for pharmaceutical and biotech companies. It is led by a strong international team and has access to all vital equipment to implement our projects.

CRESTOR is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor of cholesterol. studies in animals, and studies in cultured animal and human cells have shown rosuvastatin to have a high uptake into, and selectivity for, action in the liver, the target organ for cholesterol lowering. In and studies, rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDL. Second, rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.