Synonyms are arenols or aryl alcohols
When phenol and its derivatives are ingested as natural or-added components of food, they are rapidly absorbed from the gastrointestinal tract and participate in common pathways of metabolism (Hughes & Hall, 1995). Phenol (No. 690), phenyl acetate (No. 734), and resorcinol (No. 712), alkyl-, alkenyl-, and aryl-substituted phenols and their corresponding esters (Nos 691-712, 718, 719, 733, 735, and 737) are conjugated with sulfate or glucuronic acid and excreted primarily in the urine. The simple esters of substituted phenols undergo hydrolysis prior to conjugation. Other metabolic pathways, observed mainly at high doses, include ring hydroxylation and side-chain oxidation. Phenols containing alkoxy groups (Nos 713-717 and 720-726) and those that contain an alkyl side-chain with a ketone function (Nos 727-732 and 736) are also metabolized mainly by conjugation. Alkoxy phenols may undergo -hydroxylation before conjugation. Minor metabolites are formed through alternative pathways that include dealkylation of alkoxyphenols, reduction of side-chain ketones, side-chain oxidation, and ring hydroxylation.
Asymmetric Total Syntheses of Colchicine, β …
Organic chemistry: “Ethers”. Ethers. Williamson ether synthesis (preparation of ethers via SN2); . Digression on how to remember the -Lowry and Lewis definitions of acids and bases. Cleavage of ethers with (HX). Effect of positive formal charges on reactivity. Effect of acid or base on reactivity.
Three syntheses of the penultimate 1,3-diarylpropyl acetamide intermediate (S)-(-)-N-[1-[3-(tert-butyldimethylsilyloxy)phenyl]-3-(3,4,5-trimethoxyphenyl)propyl] acetamide (II) are described which differ in the means by which the stereogenic center was introduced.