Synthesis method of symmetric 1, 3, 4-oxadiazole - …

Synthesis and antimicrobial properties of novel 2,5-disubstituted 1,3,4-oxadiazoles.

Improved synthesis and characterisation of 1,3,4-oxadiazole

Here in, we simply report the synthesis of 1, 3, 4 oxadiazole derivatives (3a-3k) from easily available materials such as acid hydrazides and substituted aldehydes by microwave irradiation. The synthesized compounds were screened for antibacterial activity against gram positive and gram negative bacterial strain and compared it with standard drug streptomycin.

Synthesis and Pharmacological Evaluation of Some Novel 1,3,4-Oxadiazole Analogues as Anticonvulsant Agent.

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N2 - In the present study a series of new 1,3,4-oxadiazole derivatives were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 6 showed significant antibacterial activity against Candida albicans. Compound 7 showed significant antifungal activity against Escherichia coli and Pseudomonas aeruginosa.

Ali, “Synthesis and antimicrobial evaluation of newer oxadiazoles derived from phenylpropiono hydrazides”, Molecules, 14(5), pp.

79. Saitoh M, Kunitomo J, Kimura E, Hayase Y, Kobayashi H, Uchiyama N. . Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta. 2009;17:2017-29


Bachelor of Pharmacy - AIMST University

All the chemicals used were of synthetic grade (S. D. Fine .Chem. Ltd. Mumbai, India). The melting points of the synthesized compounds reported were uncorrected and recorded by open capillary method. The Micro-oven used for the synthesis is of Little Chef MS-192 W. The purity was checked by TLC. The progress of the reaction was monitored on percolated silica gel 60 F254 plates (Merck) using ethyl acetate: n-hexane (7:3) as an eluent and spot was detected by using iodine vapours. The structure of synthesized oxadiazole derivatives were confirmed by IR, H1NMR and Mass Spectral analysis. IR spectra were recorded on Perkin-Elmer spectrum in KBr. H1NMR spectra were recorded on 300MHz NMR spectrophotometer in CDCl3 by using tetra methyl silane as reference standard. Mass spectrum was recorded on GC-MS spectrophotometer and elemental analysis (C, H, N) was carried out on carlo - Erba elemental analyser.

Molecules | April 2014 - Browse Articles

Synthesis of 1-(2,5-substituted diphenyl)-1, 3, 4-oxadiazol-3(2H)-yl) ethanone(3a-3k):-

Molecules, Volume 19, Issue 4 (April 2014), Pages 3851-5458

The reactions on solid support without using solvent by microwave irradiation are recently in wide use for synthesis to create eco-friendly benign atmosphere 15. So in present work, we have developed rapid and efficient method for synthesis of 1,3,4 oxadiazoles by microwave irradiation using silica gel as solid support.

General & Introductory Chemistry

AB - In the present study a series of new 1,3,4-oxadiazole derivatives were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 6 showed significant antibacterial activity against Candida albicans. Compound 7 showed significant antifungal activity against Escherichia coli and Pseudomonas aeruginosa.