1-(1-Phenylcyclohexyl)piperidine hydrochloride: a …

Preparation and analytical characterization of 1-(1-phenylcyclohexyl)piperidine (PCP) and ..
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Felman enterprises Offer to Buy Piperidine,1-(1-phenylcyclohexyl)-

Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 956-90-1, PCP) has shown analgesic effects. Some of its derivatives were synthesized and their biological properties were studied. To date, only saturated ketones have been used as starting materials for synthesizing the phencyclidine family. In order to show desirable biological activity, the aromatic and piperidine rings are necessary for these compounds. Using alpha-tetralone as a starting material, 2-hydroxy-1-(-phenyltetralyl)piperidine, an analogue of the phencyclidine family, and some of its intermediates were synthesized. This ketone was reacted with phenyl magnesium bromide and the resultant alcohol was reacted with acetic anhydride to give alkene that was treated with potassium permanganate to give diol. This compound was treated with a suspension of sodium azide and trichloroacetic acid to give the azide compound that was reduced with LiAlH4 to give the primary amine. Cyclization of this compound with 1,5-dibromopentane finally gave a tertiary amine. It is predicted that the title compound 2-hydroxy-1-(1-phenyltetralyl)piperidine exerts a potent analgesic effect on acute and phasic pain.

Phencyclidine (1-(1-phenylcyclohexyl) piperidine; CAS 956-90-1; PCP, I) has shown analgesic effects
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1-(1-Phenylcyclohexyl)piperidine; C 17 H ..

Phencyclidine (1-(1-phenylcyclohexyl) piperi- dine, CAS 956-90-1, PCP, I) is a semi-rigid molecule containing a cyclohexane ring with attached aromatic and piperidine rings (). PCP and its analogues are highly potent and widely abused psychotomimetic drugs which influence the central nervous system. They display analgesic, stimulant, depressant and hallucinogenic effects due to specific binding sites in the brain (). PCP binds to the N-methyl-D-asparate (NMDA) receptor complex and blocks NMDA-mediated gating of the calcium conductance channel (). The analgesic effect of ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, CAS 1867-66-9, II, ), another PCP analogue, was first described by Domino et al. in 1965 (). Ketamine is a low-affinity, use-dependent, non-competitive antagonist of NMDA receptors (-).

Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 956-90-1, PCP) has shown analgesic effects.
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Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with Ketamine and PCP.

1-(1-Phenylcyclohexyl) piperidine; Formula: …
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08/09/2010 · 3719.41 Controlled substance schedules

(a) Penalty Group 2 consists of:(1) any quantity of the following hallucinogenic substances, their salts, isomers, and salts of isomers, unless specifically excepted, if the existence of these salts, isomers, and salts of isomers is possible within the specific chemical designation:5-(2-aminopropyl)benzofuran (5-APB);6-(2-aminopropyl)benzofuran (6-APB);5-(2-aminopropyl)-2,3-dihydrobenzofuran (5-APDB);6-(2-aminopropyl)-2,3-dihydrobenzofuran (6-APDB);5-(2-aminopropyl)indole (5-IT,5-API);6-(2-aminopropyl)indole (6-IT,6-API);1-(benzofuran-5-yl)-N-methylpropan-2-amine (5-MAPB);1-(benzofuran-6-yl)-N-methylpropan-2-amine (6-MAPB);Benzothiophenylcyclohexylpiperidine (BTCP);8-bromo-alpha-methyl-benzo[1,2-b:4,5-b']difuran- 4-ethanamine (trade or other name: Bromo-DragonFLY);Desoxypipradrol (2-benzhydrylpiperidine);2, 5-dimethoxyamphetamine (some trade or other names: 2, 5-dimethoxy-alpha-methylphenethylamine; 2, 5-DMA);Diphenylprolinol (diphenyl(pyrrolidin-2-yl) methanol, D2PM);Dronabinol (synthetic) in sesame oil and encapsulated in a soft gelatin capsule in a U.S.